Oleh: SRI
MAIYENA
INTISARI
Telah dilakukan
penelitian untuk mengidentifikasi glibenklamida dan bahan eksipien menggunakan
teknik Computed Radiography dan Radiation Absorption Profiler. Glibenklamida
adalah zat aktif untuk obat diabetes. Tujuan penelitian adalah mengkaji
kemampuan sistem Computed Radiography dan Radiation Absorption Profiler guna
mengidentifikasi beberapa tipe glibenklamida dan bahan eksipiennya. Pengujian
dilakukan terhadap tiga tipe glibenklamida dan tiga bahan eksipiennya, yaitu
talc, lactose dan maizestarch. Glibenklamida dan bahan eksipiennya
diidentifikasi berdasarkan profil garis citra dan profil absorpsinya untuk
memperoleh profil nilai koefisien serapan linier (µ) semua bahan.
Hasil analisis
terhadap profil garis citra untuk tegangan generator sinar-x (kV) tertentu
menunjukkan perbedaan distribusi dan profil koefisien serapan radiasi µ antara
bahan glibenklamida dengan bahan eksipiennya. Dengan cara Computed Radiography,
ketiga bahan glibenklamida dapat diidentifikasi pada tegangan 50 kV, bahan
laktose dan maizestarch dapat diidentifikasi pada tegangan 60 kV, sedangkan
talc dapat diidentifikasi baik pada tegangan 50 kV, 60 Kv maupun 70 kV. Dengan
cara Radiation Absoption Profiler, ketiga bahan glibenklamida, talc, lactose dan
maizestarch dapat dibedakan dengan baik bila digunakan tegangan 25 kV dan 35
kV. Perbedaan signifikan diperoleh untuk tegangan 35 kV.
Kata kunci: Computed Radiografi, radiation absorption
profiler, serapan radiasi, glibenklamida, eksipien
THE USE OF COMPUTED
RADIOGRAPHY AND RADIATION ABSORPTION ROFILER FOR IDENTIFICATION OF
GLIBENCLAMIDE
ABSTRACT
Research on
identification of glibenclamide and excipient materials using Computed
Radiography has been done. Glibenclamide is an active ingredient for diabetes
drug. The aims of the experiment were to assess the ability of Computed Radiography
systems and Radiation Absorption Profiler to identify several types of
glibenclamide and excipient materials. Tests performed on three types of glibenclamide
and three excipient materials, namely talc, lactose and maizestarch. Glibenclamide
and excipient materials were identified based on the image line profile and
absorption profiler to obtain linear absorption coefficient (μ) of all materials.
The results on the
image line profile for the voltage of x-ray generator (kV) showed difference on
distribution and profile of radiation absorption coefficient (μ) between
glibenclamide with materials excipient. Based on the Computed Radiography, the
three of glibenclamide can be identified at the voltage of 50 kV, lactose and
maizestarch can be identified at the voltage of 60 kV, while talc can be
identified both in voltage 50 kV, 60 kV and 70 kV. Based on the Radiation Absoption
Profiler, the three of glibenclamide, talc, lactose and maizestarch can be
distinguished very well when was used at the voltage of 25 kV and 35 kV. The significant
difference was obtained at the voltage of 35 kV.
Keywords: Computed Radiography, radiation absorption
profiler, radiation absorption, glibenclamide, excipients
