 |
| Kanker Payudara |
Oleh: Erna Fitrisia Christina
ABSTRAK
Kanker payudara adalah kanker terbanyak pada wanita di seluruh dunia dan penyebab kematian kedua dari seluruh kematian karena kanker. Kemoterapi ajuvan memberikan kemajuan bermakna pada penanganan kanker payudara. Regimen berbasis antrasiklin merupakan salah satu regimen kemoterapi ajuvan yang efektif. Keputusan pemberiannya tidak hanya termasuk data pada kekambuhan, survival dan toksisitas akut, tapi juga kualitas hidup. Kualitas hidup pasien kanker payudara juga dipengaruhi faktor sosio demografik antara lain umur, tingkat pendidikan, pekerjaan, status pernikahan.ABSTRAK
Metode penelitian menggunakan metode cohort, membandingkan nilai FACT-B pada subyek kanker payudara stadium awal sebelum kemoterapi, durante kemoterapi, 3 minggu sesudah selesai siklus kemoterapi dan 3 bulan sesudah siklus kemoterapi selesai. Selanjutnya dianalisa faktor sosiodemografik. Didapatkan 40 subyek penelitian, rerata usia 48,30±6,89 tahun. Tingkat pendidikan terbanyak adalah SMA dan perguruan tinggi yaitu 24 subyek (60%). Didapatkan 22 subyek (55%) yang masih menstruasi. Stadium II didapatkan 28 subyek (70%), stadium III didapatkan 12 subyek (30%). Regimen terbanyak dipakai adalah AC 36 subyek (90%). Didapatkan penurunan skor FACT-B durante kemoterapi terhadap skor FACT-B sebelum kemoterapi, namun tidak bermakna secara statistik (p=0,143), peningkatan skor FACT-B setelah selesai siklus kemoterapi terhadap skor FACT-B sebelum kemoterapi, namun tidak bermakna secara statistik (p=0,733). Peningkatan skor FACT-B 3 bulan sesudah siklus kemoterapi selesai terhadap skor FACT-B sebelum kemoterapi, dan bermakna secara statistik (p=0,001). Tidak didapatkan perbedaan yang bermakna secara statistik pada rerata skor FACT-B terhadap stadium tumor, status menopause, pendidikan dan pekerjaan.
Kesimpulan penelitian ini, yaitu pasien kanker payudara stadium awal yang menjalani kemoterapi ajuvan berbasis antrasiklin mengalami peningkatan skor kualitas hidup (FACT-B) yang bermakna secara statistik pada 3 bulan setelah selesai kemoterapi IV. Peningkatan skor FACT-B tersebut tidak dipengaruhi umur, status menopause, stadium tumor, pendidikan, dan pekerjaan subyek penelitian.
Kata kunci : kanker payudara, regimen berbasis antrasiklin, kualitas hidup
ABSTRACT
Breast cancer, is the leading cause of cancer among women around the world and second leading cause of cancer deaths. Adjuvant chemotherapy has proved useful to treat breast cancer. Anthracycline-based regimen have been proven and effective in adjuvant chemothetapy of breast cancer. Decision to give adjuvant chemotherapy not only including data on reccurence, survival danacut toxicity but also quality of life. Sosiodemographic factors such as age, education, ocupation, marital status also have a relationship with quality of life.This study used cohort design observing early stage breast cancer patients who receive anthracycline-based regimen chemotherapy. This study compared the changes of FACT-B score before chemotherapy, with durante chemotherapy, after complete chemotherapy IV and 3 months after complete chemotherapy cycles. The better score FACT-B reflects the better quality of life. Further analysis will be done to determine other factors that influences the changes of FACT-B score.
40 subjects eligible to the criteria, with mean age was 48,30±6,89 tahun. Most of the subjects were highschool and college, 24 subjects (60%). 22 subjects (55%) still have their menstruation. Stadium II were 28 subjects (70%), stadium III were 12 subjects (30%). Regimen AC was used in 36 subjects (90%). There was increasing in FACT-B score after completed chemotherapy cycle compared with FACT-B score before chemotherapy, and was statistically significant (p=0,001). There was no difference in FACT-B score that statistically significant in age, tumour stadium, menopausal status, education, occupation.
Early stage breast cancer subjects receive anthracyclin based regimen of adjuvant chemotherapy had better quality of life 3 months after complete chemotherapy cycles. The better FACT-B score were not influences by age, menopausal status, tumour stadium, education, and occupation.
Key words : breast cancer, anthracyclin-based regimen, quality of life.
BAB I PENDAHULUAN
A. Latar belakang
B. Pertanyaan penelitian
C. Tujuan penelitian
D. Kegunaan penelitian
E. Keaslian penelitian
BAB II TINJAUAN PUSTAKA
A. Kualitas hidup (Quality of Life)
B. Kemoterapi ajuvan pada kanker payudara
C. Kualitas hidup setelah kemoterapi ajuvan
pada kanker payudara
D. Kerangka teori
E. Kerangka konsep
F. Hipotesis
BAB III METODE PENELITIAN
A. Rancangan penelitian
B. Tempat dan waktu penelitian
C.
Populasi penelitian
D. Subyek penelitian
E. Besar sampel
F.
Protokol penelitian
G. Identifikasi Variabel
H. Definisi operasional dan pengukuran
variabel
I.
Analisis statistik
J. Pertimbangan etika penelitian
BAB IV HASIL PENELITIAN DAN PEMBAHASAN
BAB V SIMPULAN DAN SARAN
A. Simpulan
B. Saran
DAFTAR PUSTAKA
LAMPIRAN
